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The concentration of poly(ADP-ribose) Polymer/pADPr is determined by measuring light absorbance at 258 nm using the molar extinction coefficient of PAR. This measurement yields concentration in units of μM. The chain length of this polymer ranges between 2 and 300 ADP-ribose units. Because we are unable to evaluate the variation in polymer length and polymer branching, we are unable to calculate a concentration based on mass. As such, this product is bottled and sold by the concentration in molarity.

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Some evidence shows benefits of D-ribose supplements for those with low blood flow to the heart muscle, as seen in conditions like coronary artery disease. This is likely due to the role of D-ribose in producing cellular energy.

Researchers particularly saw enhanced power output and lower perceived exertion during exercise when participants with lower fitness levels took 10 grams per day of D-ribose compared to a placebo (13).

Some studies have shown that D-ribose may enhance exercise performance in those with low fitness levels or specific diseases. However, research does not support these benefits in healthy individuals.

Limited research has reported mixed results regarding the ability of D-ribose supplements to improve muscle function and well-being in people with the genetic disorder myoadenylate deaminase deficiency (MAD).

CIL offers a number of stable isotope-labeled ribose compounds. These contain different site-specific isotopic patterns (from U-13C to single, 13C or D labeled) and are supplied as neat standards for MS- or NMR-based research applications.

PAR Polymer was first synthesized using poly(ADP-ribose) polymerase (PARP) in the presence of NAD+, cleaved from PARP, and subsequently purified. The PAR Polymer is recognized by Trevigen's anti-PAR monoclonal and polyclonal antibodies.

In studies of healthy athletes, supplying fatigued muscle cells with D-ribose quickly restored ATP levels to normal. By helping to rapidly refill depleted energy stores, D-ribose may be especially beneficial for heart health.

Ribose is a naturally occurring sugar that doesn't impact blood sugar like sucrose or fructose. D-ribose has decreased blood sugar levels. If you have hypoglycemia or are taking certain types of medication, talk to your healthcare provider before you use D-ribose supplements.

While limited research suggests D-ribose may be helpful for people who have medical disorders that affect muscle function and energy levels, one study suggested it didn't improve healthy athletes' performance.

Pierce JD, Shen Q, Mahoney DE, et al. Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction. Am J Cardiol. 2022;176:79-88. doi:10.1016/j.amjcard.2022.04.031

Cao W, Qiu J, Cai T, Yi L, Benardot D, Zou M. Effect of D-ribose supplementation on delayed onset muscle soreness induced by plyometric exercise in college students. J Int Soc Sports Nutr. 2020 Aug 10;17(1):42. doi:10.1186/s12970-020-00371-8

Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol. 2014;54(5):546-554. doi:10.1002/jcph.241

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Turck D, Bresson JL, et al. Safety of D-ribose as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2018;16(5):e05265. Published 2018 May 31. doi:10.2903/j.efsa.2018.5265

Bioenergy RIBOSE is a bioactive ingredient that energizes functional foods, beverages, and nutraceuticals. Ribose is the vital structural backbone of critical cellular compounds called purines and pyrimidines. Our bodies must have an adequate supply of purines and pyrimidines to form major cellular constituents such as our genetic material (DNA and RNA), numerous cofactors, certain vitamins, and, importantly, adenosine triphosphate (ATP), the "energy currency" of the cell. Ribose is the starting point for the synthesis of these fundamental cellular compounds, and the availability of ribose determines the rate at which they can be made by our cells and tissues.

RIBOSE is unique in this metabolic role. No other compound - whether bioactive ingredient or ethical drug - can replace ribose in the important job of regulating the metabolic processes involved in synthesizing purines and pyrimidines. And, without these vital structural components, our bodies would quickly run out of energy, could not make proteins, and our cells would lose the ability to replicate.

RIBOSE is safe, clinically proven to be effective, and is protected by a family of patents covering all known uses of ribose in nutrition and medicine. Although Bioenergy RIBOSE is a five-carbon monosaccharide, it does not raise blood sugar, making it a good carbohydrate to use in food and beverage formulation. RIBOSE is highly soluble in either hot or cold solutions and tastes slightly sweet.

Our bodies make ribose naturally, but in times of stress the need is greater than our supply to satisfy the loss of energy from our cells. That is why supplementing with Bioenergy RIBOSE is so critical.

Research has also shown that ribose enhances energy recovery in heart muscle tissue after periods of restricted blood flow such as coronary heart disease, heart attack, heart surgery, or organ transplantation. Under these circumstances, the heart's functioning may be compromised and there is risk of permanent loss of heart tissue. Rigorous testing in both animal and human studies have demonstrated that supplementation of ribose restores intracellular energy levels in the cardiac muscle tissue and improves heart function.

However, under conditions of stress, injury, or aging, critical body tissues, such as the heart and skeletal muscles, cannot produce ATP quickly enough for optimal performance. D-ribose, a carbohydrate molecule found in every living organism, facilitates the production of ATP.

In studies undergone on healthy athletes, supplying cells with D-ribose quickly restored ATP levels to normal. By helping to rapidly refill depleted energy, it may be especially beneficial for heart health.

However, under conditions of stress, injury, or aging, critical body tissues, such as heart and skeletal muscles, cannot produce ATP quickly enough for optimal performance. D-ribose, a carbohydrate molecule found in every living organism, facilitates the production of ATP.

Ribose is a sugar that is made in your body as you metabolize glucose. D-ribose is the building block of ATP, the cellular energy currency. ATP is a molecule that contains very high-energy bonds that can be used to power important chemical reactions for essential bodily functions. The mitochondria make sure that the body has sufficient levels of ATP for all of those functions. Only when your cells have both the energy required to perform their functions and the materials to make ATP can the rest of your body function properly.

When you ingest glucose-containing food, your body processes it through multiple pathways. One pathway generates ribose, which signals the body to synthesize ATP. Another pathway activates the breakdown of glucose through glycolysis, harnessing the released energy to form ATP through other processes.

In addition, just as ribose is the building block for ATP, collagen is a building block for many proteins in our body. Collagen contains many amino acids that the human body cannot generate itself. These amino acids must be consumed by eating protein, especially meat, or through proper supplementation.

Collagen supplementation is thought to particularly help with inflammation, joint pain, and muscle function, all of which are often affected by Adrenal Fatigue. Thus, ribose and collagen can work together in your muscles to decrease pain, help increase your energy levels, and get you up and moving again.

When ribose is present at sufficient levels in the cell, it stimulates the formation of the ATP. When this occurs, there is plenty of ATP to perform cell functions. In normal, healthy cells, enough ribose is present because the pentose shunt from glucose is able to keep up with the demand. In some cases, however, as in those with chronic stress, the cells cannot keep up with the demand. This is when cells begin to fatigue.

Ribose will also help if the cause of Adrenal Fatigue and hormone imbalance is actually a mitochondrial deficiency. If a dysfunction in the mitochondria is the underlying cause of the symptoms, D-ribose will help to bringing the body back into balance.

The mitochondria thus power the cleaning out of the cells and extracellular matrix. Those with Adrenal Fatigue, often have many toxins that have built up in the body, so it is important for the mitochondria to function properly. D-ribose supports the mitochondria, which in turn supports the detoxification of the extracellular matrix.

D-ribose is also unique in that it does not raise your blood sugar, unlike glucose and fructose (sugar from fruits), even though it is also a sugar. It therefore enhances energy flow without causing hyperglycemia. D-ribose is generally safe as a short-term supplement for those recovering from Adrenal Fatigue. However, D-ribose side-effects include diarrhea, nausea, headache, and stomach discomfort. It also has been shown to cause a drop in blood sugar levels. This might seem counter-intuitive, given that D-ribose is a sugar, but because it is a sugar, it triggers the secretion of insulin. Insulin is a hormone that is released by the pancreas and manages the breakdown of glucose, the main sugar in the human diet. When taking a D-ribose supplement however, insulin breaks down glucose in the bloodstream despite not having consumed glucose. This causes a drop in blood sugar. If you have diabetes or hypoglycemia, or are otherwise sensitive to changes in blood sugar, you should not take D-ribose. If you take any prescription drugs or other supplements that are shown to decrease blood sugar levels, you should also be careful of the combination. Always take D-ribose with food, or other compounds such as collagen, to reduce metabolic swings, which are especially common in those who are weak or have sensitive bodies. The combination of D-ribose and collagen is ideal to provide metabolic stability, increased energy, and support for the adrenal glands in times of stress. 041b061a72


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